Beings from a different dimension have started a war with mankind. To counter this threat, an academy called "Genetics" that trains female warriors called "Pandora," who can wield special weaponry and armor, was formed. Kazuya Aoi decided to enroll in this school because of a promise with his sister, an outstanding alumnus who died in battle. There he meets second year Satellizer L. Bridgette, nicknamed "The Untouchable Queen" due to her solitary demeanor but also top of her class whose battle simulation streak is undefeated, until he came... and slowly changed her.